Chelating agents in the treatment of acute vanadyl sulphate intoxication in mice
Domingo, JL; Gomez, M; Llobet, JM; Corbella, J
HERO ID
2072271
Reference Type
Journal Article
Year
1990
Language
English
| HERO ID | 2072271 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Chelating agents in the treatment of acute vanadyl sulphate intoxication in mice |
| Authors | Domingo, JL; Gomez, M; Llobet, JM; Corbella, J |
| Journal | Toxicology |
| Volume | 62 |
| Issue | 2 |
| Page Numbers | 203-211 |
| Abstract | The efficacy of chelating agents for treating acute vanadyl-sulfate (27774136) intoxication was studied in mice. Swiss-albino-mice were injected intramuscularly with 215 to 4640mg/kg vanadyl-sulfate as the pentahydrate. They were injected 10 minutes later with one of 18 chelating or reducing agents at concentrations of up to 804mg/kg. Fourteen day mortality was recorded to determine the median lethal doses (LD50s). The effectiveness of the agents was assessed by determining the therapeutic efficiency (TEF), the ratio of the LD50 for the combined treatment to the LD50 of vanadyl-sulfate alone. EDTA, glutathione, succinic-acid, monosodium-phosphate, diethylenetriaminepentaacetic-acid (DTPA), and 2-mercaptosuccinic-acid (2MC) enhanced survival and had TEFs above 1.00. Mice were injected with 334mg/kg vanadyl-sulfate followed 10 minutes later by EDTA, glutathione, succinic-acid, monosodium-phosphate, DTPA, 2MC, deferoxamine-mesylate, ascorbic-acid, or Tiron to examine their effects on urinary and fecal excretion and the tissue distribution of vanadium (7440622). Urine was the major route for vanadium excretion, 33% of the dose being excreted over 24 hours. Tiron, ascorbic-acid, and 2MC significantly increased urinary excretion of vanadium. The largest concentration of vanadium was found in the kidney, followed by the liver, spleen, heart, and brain, in that order. Tiron, EDTA, and 2MC significantly decreased vanadium concentrations in the kidney. Tiron and DTPA significantly decreased liver vanadium concentrations. EDTA, glutathione, monosodium-phosphate, Tiron, and DTPA decreased vanadium concentrations in the heart. None of the compounds significantly affected brain aluminum concentration. The authors conclude that Tiron is the most effective agent of those tested for removing vanadium after treatment with vanadyl-sulfate. |
| Doi | 10.1016/0300-483X(90)90110-3 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |