EFFECTS OF PHOSPHORYLATION OF CHRYSOTILE ON PLEUROPULMONARY FIBROGENICITY AND CARCINOGENICITY
Daniel, H; Wastiaux, A; Sebastien, P; Begin, R
HERO ID
2090108
Reference Type
Journal Article
Year
1993
Language
English
PMID
| HERO ID | 2090108 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | EFFECTS OF PHOSPHORYLATION OF CHRYSOTILE ON PLEUROPULMONARY FIBROGENICITY AND CARCINOGENICITY |
| Authors | Daniel, H; Wastiaux, A; Sebastien, P; Begin, R |
| Journal | British Journal of Industrial Medicine |
| Volume | 50 |
| Issue | 2 |
| Page Numbers | 167-171 |
| Abstract | Long term inhalation in Wistar-rats, intrapleural injection in Wistar-rats, and injection into the tracheal lobe of sheep were used to determine the effects of phosphorylation of chrysotile (12001295) on its subsequent pleuropulmonary effects. Studies were also performed using native, untreated, chrysotile fibers. Phosphorylated chrysotile (chrysophosphate) or chrysotile was administered to sheep by bronchoscopic catheterization and slow infusion in the tracheal lobe. Rats were administered chrysotile, chrysophosphate or titanium-oxide by intrapleural injection. For the inhalation study, rats were exposed whole body for 5 hours/day, 5 days/week for 24 months to chrysotile, chrysophosphate or titanium-oxide. Chrysophosphate and chrysotile exhibited similar pulmonary fibrogenicity in sheep and rats in these studies. During the final 6 months of the intrapleural rat study, mortality was higher in the chrysotile group and related to histologically identified mesotheliomas. The incidence of such tumors was lower in the chrysophosphate group, but not significantly so. The long term inhalation study did not show less pulmonary carcinogenicity for chrysophosphate. Squamous carcinomas occurred with greater frequency in the chrysophosphate than chrysotile exposed animals. The particular surface modifications induced by chrysophosphate treatment were ineffective in reducing the long term fibrogenicity and carcinogenicity of chrysotile in these animals. |
| Doi | 10.1136/oem.50.2.167 |
| Pmid | 8382077 |
| Wosid | WOS:A1993KJ98000011 |
| Url | http://oem.bmj.com/cgi/doi/10.1136/oem.50.2.167 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Index Medicus |