Subacute 2-AAF toxicity in C57BL/6 and BALB/c strain mice
Schieferstein, G; Haley, TJ
HERO ID
2147642
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2147642 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Subacute 2-AAF toxicity in C57BL/6 and BALB/c strain mice |
| Authors | Schieferstein, G; Haley, TJ |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 105 |
| Abstract | Ninety-day subacute toxicity of 2-acetylaminofluorene (2-AAF) has been determined in 1200 mice each of the C57BL/6 and BALB/c strains equally divided between the sexes. The concentrations of 2-AAF were 0.05, 0.025, 0.01, 0.005 and 0.001% of the diet. No signs of toxicity were seen. Slight weight reduction was seen in the C57BL/6 males and BALB/c females at the 0.05% AFF level. A dose-dependent urinary bladder epithelial hyperplasia was seen in both strains and the males were more susceptible than the females. Squamous metaplasia of the uroepithelium was observed in the BALB/c mice with this effect greater in the males. One BALB/c male at the 0.025 and 0.05% levels had bladder carcinoma. Adrenal gland spindle cell hyperplasia was greater in the females of both strains. Bladder concretions were observed in males of both strains. No other significant histopathological changes were observed. The data obtained will be utilized in the design of the large chronic studies to be conducted at NCTR. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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