Organochlorine compounds, nitro musks and perfluorinated substances in breast milk - Results from Bavarian Monitoring of Breast Milk 2007/8
Raab, U; Albrecht, M; Preiss, U; Völkel, W; Schwegler, U; Fromme, H
HERO ID
2149742
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 2149742 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Organochlorine compounds, nitro musks and perfluorinated substances in breast milk - Results from Bavarian Monitoring of Breast Milk 2007/8 |
| Authors | Raab, U; Albrecht, M; Preiss, U; Völkel, W; Schwegler, U; Fromme, H |
| Journal | Chemosphere |
| Volume | 93 |
| Issue | 3 |
| Page Numbers | 461-467 |
| Abstract | The aim of the Bavarian Monitoring of Breast Milk (BAMBI) project was to examine 10 organochlorine pesticides (OPs), 3 nitro musks, 6 indicator polychlorinated biphenyls (PCBs), 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs), 12 dioxin-like PCBs (dl-PCBs) and several perfluorinated alkyl compounds in breast milk samples. A total of 516 breast milk samples were collected from seven regions in Bavaria and were analyzed by means of GC/ECD, GC/HRMS, and LC/MS-MS. Concerning the OPs, only hexachlorobenzene and a metabolite of DDT, 1,1-dichloro-2,2-bis(4-chlorophenyl) ethylene (p,p'-DDE), could be quantified in all samples (median: 16 ngg(-1) lipid and 63 ngg(-1) lipid, respectively). Median concentrations of 150 ngg(-1) lipid (range: 3-1900 ngg(-1) lipid) were found for the sum of the indicator PCBs. The concentrations of the PCDDs/PCDFs and the dl-PCBs ranged from 0.8 to 15.1 (median 5.7) pg WHO-TEQ1998g(-1) lipid and from 1.5 to 18.9 pg (median 6.4) WHO-TEQ1998 g(-1) lipid, respectively. The median perfluorooctane sulfonate concentration was 0.05 μgL(-1) (range: <0.02-0.26 μgL), while the other PFCs were observed only in a subset of samples. On the basis of the median and 95th percentile concentration, "medium" and "high" intake levels were estimated for a 3-month-old exclusively breastfed infant. In particular, "medium" and "high" intake levels were calculated of 69 and 133 pg WHO1998 TEQ kg(-1) b.w. for PCDDs/PCDFs, 8 and 21 ngkg(-1) b.w. for dl-PCBs, and 6 and 25 ngkg(-1) b.w. for perfluorooctane sulfonate, respectively. The calculated intake for perfluorinated substances is clearly below the tolerable daily intake (TDI), while the established TDI values are still clearly exceeded for PCDDs/PCDFs and dl-PCBs. |
| Doi | 10.1016/j.chemosphere.2013.06.013 |
| Pmid | 23856469 |
| Wosid | WOS:000324456700001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Breast milk; Biomonitoring; Chlorinated and fluorinated POPs; Infant exposure |
| Relationship(s) |
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