Effect of isomerically pure chlorobiphenyls on structure of kidney tubules in rat
Hansell, MM; Ecobichon, DJ
HERO ID
2165125
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2165125 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Effect of isomerically pure chlorobiphenyls on structure of kidney tubules in rat |
| Authors | Hansell, MM; Ecobichon, DJ |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 102-103 |
| Abstract | Commercial polychlorinated biphenyls are mixtures of various compounds with only the total chlorination determined. Studies of the effects of isomerically-pure chlorobiphenyls on liver carried out in these laboratories showed that the effect of the compound was related to the position and degree of chlorination. In a parallel study, an attempt was made to determine if there was a similar relationship in kidney. The agents used were Aroclors 1254 and 1260, biphenyl and a series of isomerically-pure mono-, di-, tetra-, hexa-, and octochloro-biphenyls. Groups of 50-60 g male Woodlyn Wistar rats were injected (ip) with agent dissolved in peanut oil at a dosage of 50 mg/kg/day for 3 days, and killed with chloroform 4 days after the final injection. Samples of kidney were immediately fixed by immersion in 1% OsO4 for electron microscopy. In a second experiment, groups of rats were injected with 3 compounds ( 4-mono-, 4,4' -di- and 2,5,2',5'-tetrachlorobiphenyl) at a rate of 100 mg/kg/day for 7 days and killed 1 day later. The glomerulus appeared to be unaffected by treatment, but alterations could be found in renal tubule cells. These included increases in the number of vacuoles, lipid droplets, microbodies, lysosomes and smooth endoplasmic reticulum. Some tubule cells contained mitochondria having altered morphology and disruption of the ordered appearance of the basal in foldings of the plasma membrane. In both experiments, biphenyl and mono- and dichlorobiphenyls caused more marked changes than did the more highly chlorinated compounds. |
| Wosid | WOS:A1974T653800076 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, DC |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10-14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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