Genetics of murine lung tumors
Dragani, TA; Manenti, G; Pierotti, MA
HERO ID
2216259
Reference Type
Book/Book Chapter
Year
1995
Language
English
PMID
| HERO ID | 2216259 |
|---|---|
| Year | 1995 |
| Title | Genetics of murine lung tumors |
| Book Title | Advances in cancer research: Volume 67 |
| Authors | Dragani, TA; Manenti, G; Pierotti, MA |
| Editor | Vande Woude, GF; Klein, G |
| Publisher Text | Academic Press |
| City | San Diego, CA |
| Page Numbers | 83-112 |
| Abstract | This chapter focuses on the genetics of murine lung tumors. Some studies indicate that susceptibility to lung tumorigenesis is determined by a single gene, while other studies suggest the involvement of multiple genes. Most studies on the genetics of lung tumorigenesis in mice have considered tumor incidence and the number of tumors per animal as the phenotype, without considering the size of neoplastic lesions. There is no relationship between the susceptibility of any given mouse strain to lung tumors and its susceptibility to tumors of other organs. Susceptibility to spontaneous lung tumor development is paralleled by susceptibility to the induction of the same tumor type by chemical carcinogens. The study and identification of genetic factors affecting inherited predisposition to lung tumorigenesis in mice are of great interest as a model system for understanding pathogenetic mechanisms. Inbred mice represent good model systems for the identification of the number and chromosomal localization of genetic loci predisposing lung tumor development. The knowledge of the genetics of lung tumor susceptibility in mice is growing very quickly. Lung tumor is a relatively common type of cancer in humans, and the familial clustering of cases is rare compared to colon and breast cancer, where both nonhereditary and familial cases are recognized. The murine strains predisposed to lung tumor development may provide a unique experimental system for the analysis of the genetics of these tumors. |
| Doi | 10.1016/S0065-230X(08)60711-3 |
| Pmid | 8571820 |
| Is Certified Translation | No |
| Dupe Override | No |
| Isbn | 9780120066674 |
| Is Public | Yes |
| Language Text | English |