Influence of breathing mode and activity level on the regional deposition of inhaled particles and implications for regulatory standards
Miller, FJ; Martonen, TB; Ménache, MG; Graham, RC; Spektor, DM; Lippmann, M
HERO ID
23106
Reference Type
Book/Book Chapter
Year
1988
Language
English
| HERO ID | 23106 |
|---|---|
| Year | 1988 |
| Title | Influence of breathing mode and activity level on the regional deposition of inhaled particles and implications for regulatory standards |
| Book Title | Inhaled particles VI: Proceedings of an international symposium and workshop on lung dosimetry |
| Authors | Miller, FJ; Martonen, TB; Ménache, MG; Graham, RC; Spektor, DM; Lippmann, M |
| Editor | Dodgson, J; McCallum, RI; Bailey, MR; Fisher, DR |
| Publisher Text | British Occupational Hygiene Society |
| City | Derby, United Kingdom |
| Abstract | Particulate size-selective sampling is an important consideration in determining ambient air quality standards and threshold limit values for workplace exposures. Hazard evaluations, as well as risk analyses, can benefit from an improved understanding of factors affecting regional respiratory tract deposition of particles in man. Here, thoracic deposition and its component parts are examined, as a function of particulate size, for ventilation rates ranging from normal respiration to heavy exercise in individuals who are habitual mouth breathers and in those who normally employ oronasal breathing when minute ventilations exceed approximately 35 Lmin(-1). Nonlinear regression techniques were used to fit logistic models of the form Y = [1 + e("small alpha" + "small beta"log X) ](-1) to data from tests measuring extrathoracic (ET) and tracheobronchial (TB) deposition. X was defined as an impaction parameter ("small rho" d(2)Q) and as the aerodynamic diameter of the particle (D(ae)) for ET and TB deposition, respectively. The logistic models yielded significantly improved fits of the experimental data compared with previously used linear regression models. Our analyses demonstrate that the activity level of the exposed population should be taken into account to assess the potential health consequences from ambient or workplace exposures. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Cambridge, United Kingdom |
| Isbn | 9781483159782 |
| Conference Name | Proceedings of an international symposium and workshop on lung dosimetry |
| Conference Date | September 2–6, 1985 |
| Is Public | Yes |
| Language Text | English |