A subchronic (180-day) oral toxicity study of ethyl tertiary-butyl ether, a bioethanol, in rats
Miyata, K; Koga, T; Aso, S; Hoshuyama, S; Ajimi, S; Furukawa, K
HERO ID
2321109
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 2321109 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | A subchronic (180-day) oral toxicity study of ethyl tertiary-butyl ether, a bioethanol, in rats |
| Authors | Miyata, K; Koga, T; Aso, S; Hoshuyama, S; Ajimi, S; Furukawa, K |
| Journal | Drug and Chemical Toxicology |
| Abstract | Abstract A subchronic (180-day) toxicity study was conducted to evaluate the effects of ethyl tertiary-butyl ether (ETBE), a biomass fuel, in male and female rats. ETBE was administered at dose levels of 0, 5, 25, 100 and 400 mg/kg/body weight (b.w.)/day by gavage. No treatment-related adverse effects were observed at 5, 25 or 100 mg/kg. Centrilobular hypertrophy of hepatocytes was observed in males and females and their relative liver weights were increased, suggesting enhanced metabolic activity. From these results, we concluded that the no observed adverse effect level of ETBE was 100 mg/kg b.w./day under the conditions tested. |
| Doi | 10.3109/01480545.2013.851690 |
| Pmid | 24252074 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |