Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp 16-02-1
Chen, X; Li, C; Cui, C; Hua, Wei; Zhu, TJ; Gu, Q
HERO ID
2524275
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2524275 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Nine New and Five Known Polyketides Derived from a Deep Sea-Sourced Aspergillus sp 16-02-1 |
| Authors | Chen, X; Li, C; Cui, C; Hua, Wei; Zhu, TJ; Gu, Q |
| Journal | Marine Drugs |
| Volume | 12 |
| Issue | 6 |
| Page Numbers | 3116-3137 |
| Abstract | Nine new C-9 polyketides, named aspiketolactonol (1), aspilactonols A-F (2-7), aspyronol (9) and epiaspinonediol (11), were isolated together with five known polyketides, (S)-2-(2'-hydroxyethyl)-4-methyl-gamma-butyrolactone (8), dihydroaspyrone (10), aspinotriol A (12), aspinotriol B (13) and chaetoquadrin F (14), from the secondary metabolites of an Aspergillus sp. 16-02-1 that was isolated from a deep-sea sediment sample. Structures of the new compounds, including their absolute configurations, were determined by spectroscopic methods, especially the 2D NMR, circular dichroism (CD), Mo-2-induced CD and Mosher's H-1 NMR analyses. Compound 8 was isolated from natural sources for the first time, and the possible biosynthetic pathways for 1-14 were also proposed and discussed. Compounds 1-14 inhibited human cancer cell lines, K562, HL-60, HeLa and BGC-823, to varying extents. |
| Doi | 10.3390/md12063116 |
| Pmid | 24871461 |
| Wosid | WOS:000338189200002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Aspergillus sp 16-02-1; fungal strain from deep sea sediment; aspiketolactonol; aspilactonol; aspyronol; lactone; epiaspinonediol; polyketide; structure; cytotoxicity |