Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: Results of the LARS study
Lehmann, I; Rehwagen, M; Diez, U; Seiffart, A; Rolle-Kampczyk, U; Richter, M; Wetzig, H; Borte, M; Herbarth, O
HERO ID
25826
Reference Type
Journal Article
Year
2001
Language
English
PMID
| HERO ID | 25826 |
|---|---|
| In Press | No |
| Year | 2001 |
| Title | Enhanced in vivo IgE production and T cell polarization toward the type 2 phenotype in association with indoor exposure to VOC: Results of the LARS study |
| Authors | Lehmann, I; Rehwagen, M; Diez, U; Seiffart, A; Rolle-Kampczyk, U; Richter, M; Wetzig, H; Borte, M; Herbarth, O |
| Journal | International Journal of Hygiene and Environmental Health |
| Volume | 204 |
| Issue | 4 |
| Page Numbers | 211-221 |
| Abstract | The association between indoor exposure to volatile organic, compounds (VOC), prevalence of allergic sensitization and cytokine secretion profile of peripheral T cells was studied in 3 year old children of the LARS study (Leipzig Allergy Risk Children Study) to investigate the role of VOC exposure as a risk factor for the development of atopic disease. Indoor VOC exposure was measured over a period of 4 weeks in infants' bedrooms using a passive sampling system. Specific IgE antibodies to food, indoor and outdoor allergens were measured by the Pharmacia CAP system and correlated to VOC exposure (n= 120). In addition, cytokine producing peripheral T cells (interleukin(IL)-4, inrerferon(IFN)-y) were measured in a subgroup of 28 children by means of intracellular cytokine staining. For the first time we were able to show that exposure to alkanes (C6, C9, ClO) and aromatic compounds (toluene, o-xylene, m + p-xylene, 2-, 3- and 4-ethyl-toluene, chlorobenzene) may contribute to the risk of allergic sensitization to the food allergens milk and egg white (Odds ratios between 5.7 and 11.2). Moreover, significantly reduced numbers of CD3 +/ CD8 + peripheral T cells were found in children exposed to alkanes (C9-C13), naphthalene and chlorobenzene. Exposure to benzene, ethylbenzene and chlorobenzene was associated with higher percentages of IL-4 producing CD3+T cells. Both an increase in IL-4 producing type 2 T cells and a reduction of IFN-y producing type 1 T cells may contribute to a type 2 skewed memory in response to allergens. Therefore, we suggest exposure to VOCs in association with allergic sensitization to be mediated by a T cell polarization toward the type 2 phenotype. |
| Doi | 10.1078/1438-4639-00100 |
| Pmid | 11833293 |
| Wosid | WOS:000173513200002 |
| Url | <Go to ISI>://WOS:000173513200002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Int. J. Hyg. Environ. Health 204: 211-221. |
| Is Public | Yes |
| Language Text | English |
| Keyword | VOC; IgE; type 1 T cells; type 2 T cells; Th1; Th2; children; allergy |
| Is Qa | No |