Effect of the intravenous lipid emulsions on the availability of calcium when using organic phosphate in TPN admixtures
Chaieb D, S; Chaumeil, JC; Jebnoun, S; Khrouf, N; Hedhili, A; Sfar, S
HERO ID
2599748
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 2599748 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Effect of the intravenous lipid emulsions on the availability of calcium when using organic phosphate in TPN admixtures |
| Authors | Chaieb D, S; Chaumeil, JC; Jebnoun, S; Khrouf, N; Hedhili, A; Sfar, S |
| Journal | Pharmaceutical Research |
| Volume | 25 |
| Issue | 11 |
| Page Numbers | 2545-2554 |
| Abstract | <strong>PURPOSE: </strong>The addition of high amounts of calcium remains a pharmaceutical concern due to its precipitation with phosphate in total parenteral nutrient (TPN) admixtures, compromising also the stability of the lipid emulsion.<br /><br /><strong>MATERIALS AND METHODS: </strong>Calcium-phosphate solubility was compared when using binary PN solutions versus all-in-one TPN (admixtures with lipid emulsions) in three formulas using organic calcium gluconate and glucose-1-phosphate.<br /><br /><strong>RESULTS: </strong>It was found that variation of Ca-P solubility exists between formulation with or without lipid emulsions. Concentrations of Ca decreased after filtrations of all admixtures (from 5% to 30%) and it was more significant in binary solutions. Precipitation has been observed by microscopy at high concentrations of both organic Ca-P after critical conditions of storage (24 h at 37 degrees C plus one day at ambient temperature) for admixtures containing 1% amino acids and 8% glucose with or without lipids compared to admixtures containing 2% or 3.5% amino acids and 14% glucose.<br /><br /><strong>CONCLUSIONS: </strong>These data demonstrated that availability of Ca using organic glucose-1-phosphate increased when lipids were present in TPN admixtures, without alteration of the lipid emulsion. Thus, high amounts of Ca (up to 30 mmol/l) and phosphates (up to 40 mmol/l) might be provided safely in parenteral nutrition admixtures. |
| Doi | 10.1007/s11095-008-9671-7 |
| Pmid | 18719980 |
| Wosid | WOS:000259742300009 |
| Is Certified Translation | No |
| Dupe Override | 2599748 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pharmacology; Parenteral nutrition |
| Relationship(s) |
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