Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel
Rodrigues, EG; Smith, K; Maule, AL; Sjodin, A; Li, Z; Romanoff, L; Kelsey, K; Proctor, S; Mcclean, MD
HERO ID
2708930
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2708930 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Urinary polycyclic aromatic hydrocarbon (OH-PAH) metabolite concentrations and the effect of GST polymorphisms among US Air Force personnel exposed to jet fuel |
| Authors | Rodrigues, EG; Smith, K; Maule, AL; Sjodin, A; Li, Z; Romanoff, L; Kelsey, K; Proctor, S; Mcclean, MD |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 56 |
| Issue | 5 |
| Page Numbers | 465-471 |
| Abstract | <strong>OBJECTIVE: </strong>To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms.<br /><br /><strong>METHODS: </strong>Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites.<br /><br /><strong>RESULTS: </strong>Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol (β = 0.17; P = <0.0001), 2-naphthol (β = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations (β = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1.<br /><br /><strong>CONCLUSIONS: </strong>USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene. |
| Doi | 10.1097/JOM.0000000000000142 |
| Pmid | 24806557 |
| Wosid | WOS:000335866500003 |
| Url | <Go to ISI>://WOS:000335866500003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Health & Safety Science Abstracts; Absorption; Naphthalene; Polycyclic aromatic hydrocarbons; Metabolites; Air sampling; Metabolism; Inhalation; Shift work; H 1000:Occupational Safety and Health |