Induction of tumors in nonhuman primates with various chemical carcinogens
Adamson, RH; Correa, P; Dalgard, DW
HERO ID
2735342
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2735342 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Induction of tumors in nonhuman primates with various chemical carcinogens |
| Authors | Adamson, RH; Correa, P; Dalgard, DW |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 93 |
| Abstract | Various chemicals which are carcinogenic in rodents have been evaluated for their carcinogenic potential in non-human primates, primarily rhesus and cynomolgus monkeys. Among carcinogens evaluated were various polycyclic hydrocarbons, fluorenylacetamides, azo dyes, urethane, various nitroso compounds, aflatoxin Bi. cycasin and its aglycone and procarbazine. Liver tumors have been induced by ip and/or oral N-nitrosodiethylamine (DENA), 1-nitrosopiperidine, N-nitrosodipropylamine, aflatoxin B1 and cycasin. Leukemias and lymphomas have been induced following administration of procarbazine and squamous cell carcinoma of the oral cavity and esophagus has been induced by oral administration of methylnitrosourea. DENA is the most potent liver carcinogen thus far tested. After ip administration of DENA every other week to newborn rhesus monkeys, 100 % of the monkeys developed tumors within 10-15 months. All of the monkeys developed a significant elevation in alpha fetoprotein levels 3-6 months in advance of gross or histologic evidence of tumors. Thus the non-human primates are good models for evaluating potential carcinogens and for developing biological markers for detecting preneoplastic changes as well as frank neoplasia. |
| Wosid | WOS:A1974T653800051 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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