Antitumour activity of coumarin in prostate and mammary cancer models
von Angerer, E; Kager, M; Maucher, A
| HERO ID | 2756722 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | Antitumour activity of coumarin in prostate and mammary cancer models |
| Authors | von Angerer, E; Kager, M; Maucher, A |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 120 Suppl |
| Page Numbers | S14-S16 |
| Abstract | The antineoplastic and antimetastatic activities of coumarin were evaluated in transplanted prostate tumours of the rat. The growth of Noble Nb-R prostate tumours was strongly inhibited by coumarin (40 mg/kg; administered three times per week), whereas the hormonally more sensitive Dunning R3327-G rat prostate carcinoma did not respond. Coumarin was also shown to possess antimetastatic activity in a Dunning R3327-MatLu tumour model. The number of lung metastases was reduced significantly by 40%-50% following the administration of coumarin (40 mg daily). Preliminary data from experiments with rats bearing DMBA-induced mammary carcinomas showed that these tumours are as sensitive to coumarin as Noble-R-prostate tumours. |
| Pmid | 8132695 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |