Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa
Song, WH; Cheng, ZH; Chen, DF
| HERO ID | 2899362 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa |
| Authors | Song, WH; Cheng, ZH; Chen, DF |
| Journal | Journal of Natural Products |
| Volume | 77 |
| Issue | 1 |
| Page Numbers | 42-48 |
| Abstract | Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa. The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade. |
| Doi | 10.1021/np400571x |
| Pmid | 24377852 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |