[Protective effect of Acai berries on chronic alcoholic hepatic injury in rats and their effect on inflammatory cytokines]
Qu, SS; Zhang, JJ; Li, YX; Zheng, Y; Zhu, YL; Wang, LY
| HERO ID | 2902097 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | [Protective effect of Acai berries on chronic alcoholic hepatic injury in rats and their effect on inflammatory cytokines] |
| Authors | Qu, SS; Zhang, JJ; Li, YX; Zheng, Y; Zhu, YL; Wang, LY |
| Journal | Zhongguo Zhongyao Zazhi / China journal of Chinese materia medica |
| Volume | 39 |
| Issue | 24 |
| Page Numbers | 4869-4872 |
| Abstract | <strong>OBJECTIVE: </strong>To study the protective effect of Acai berries(Euterpe oleraceae) on chronic alcoholic hepatic injury in rats and their mechanism.<br /><br /><strong>METHOD: </strong>Wistar rats were fed for 1 week and randomly divided into blank group, model group, Dongbao Gantai group, Acai 1.6, 0.8, 0.4 g . kg-1 groups. The blank group was given distilled water, and the other groups were orally given 56% white spirit (Erguotou) for eight weeks at the dosages of 8 mL . kg-1 in the 1st week, which increased by 0.1 mL week by week till to 15 mL . kg-1, in order to establish the chronic hepatic injury model, and observe the effect of Acai berry freeze-dried powder on hepatocyte membrane permeability, liver lipid peroxidation, changes in inflammatory cytokines and pathological changes in hepatocytes.<br /><br /><strong>RESULT: </strong>Acai berries could significantly reduce serum ALT and AST(P<0.05), MDA(P<0.05), TG(P<0.05) and serum TNF-α and IL-6(P <0.05) and increase GSH and SOD(P <0.05). According to liver histopathological observation, livers in the model group were dominated by steatosis, some livers suffered spotty necrosis and inflammatory cell infiltration; The positive drug and Acai groups showed different changes in pathologic changes in rat livers.<br /><br /><strong>CONCLUSION: </strong>Acai berries show s specific protective effect on alcoholic hepatic injury. Its mechanism may be correlated with the inhibition of such inflammatory factors as TNF-α and IL-6. |
| Pmid | 25898594 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Chinese |