MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene
Lv, L; Li, Y; Deng, H; Zhang, C; Pu, Y; Qian, L; Xiao, J; Zhao, W; Liu, Q; Zhang, D; Wang, Y; Zhang, H; He, Y; Zhu, J
HERO ID
2902356
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 2902356 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene |
| Authors | Lv, L; Li, Y; Deng, H; Zhang, C; Pu, Y; Qian, L; Xiao, J; Zhao, W; Liu, Q; Zhang, D; Wang, Y; Zhang, H; He, Y; Zhu, J |
| Journal | Cancer Letters |
| Volume | 357 |
| Issue | 1 |
| Page Numbers | 105-113 |
| Abstract | Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2. Here, we showed that as a new direct target, the homeobox C9 (HOXC9) gene also executes the promoting effect of miR-193a-3p on the bladder cancer chemoresistance from a systematic study of multi-chemosensitive (5637) and resistant (H-bc) bladder cancer cell lines in both cell culture and tumor-xenograft/nude mice system. Paralleled with the changes in the drug-triggered cell death, the activities of both DNA damage response and oxidative stress pathways were drastically altered by a forced reversal of miR-193a-3p or HOXC9 levels in bladder cancer cells. In addition to a new mechanistic insight, our results provide a set of the essential genes in the miR-193a-3p/HOXC9/DNA damage response/oxidative stress pathway axis as the diagnostic targets for the guided anti-bladder cancer chemotherapy. |
| Doi | 10.1016/j.canlet.2014.11.002 |
| Pmid | 25444900 |
| Wosid | WOS:000348084100010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |