Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease
Young Jeong, J; Sperry, J; Taylor, JA; Brimble, MA
| HERO ID | 2902388 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease |
| Authors | Young Jeong, J; Sperry, J; Taylor, JA; Brimble, MA |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 87 |
| Page Numbers | 220-227 |
| Abstract | 9-Deoxy analogues of the HRV 3C protease inhibitor (-)-thysanone display better inhibitory properties than the natural product, inferring the C9-OH hinders binding to the enzyme. |
| Doi | 10.1016/j.ejmech.2014.09.063 |
| Pmid | 25259514 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |