In vitro studies of the activity of dithiocarbamate organoruthenium complexes against clinically relevant fungal pathogens
Donnici, CL; Nogueira, LJ; Araujo, MH; Oliveira, , SR; Magalhães, TF; Lopes, MT; Araújo e Silva, AC; Ferreira, AM; Martins, CV; de Resende Stoianoff, MA
| HERO ID | 2902640 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | In vitro studies of the activity of dithiocarbamate organoruthenium complexes against clinically relevant fungal pathogens |
| Authors | Donnici, CL; Nogueira, LJ; Araujo, MH; Oliveira, , SR; Magalhães, TF; Lopes, MT; Araújo e Silva, AC; Ferreira, AM; Martins, CV; de Resende Stoianoff, MA |
| Journal | Molecules |
| Volume | 19 |
| Issue | 4 |
| Page Numbers | 5402-5420 |
| Abstract | The in vitro antifungal activity of nine dirutheniumpentadithiocarbamate complexes C1-C9 was investigated and assessed for its activity against four different fungal species with clinical interest and related to invasive fungal infections (IFIs), such as Candida spp. [C. albicans (two clinical isolates), C. glabrata, C. krusei, C. parapsolisis, C. tropicalis, C.dubliniensis (six clinical isolates)], Paracoccidioides brasiliensis (seven clinical isolates), Cryptococcus neoformans and Sporothrix schenckii. All synthesized complexes C1-C9 and also the free ligands L1-L9 were submitted to in vitro tests against those fungi and the results are very promising, since some of the obtained MIC (minimal inhibitory concentration) values were very low (from 10-6 mol mL-1 to 10-8 mol mL-1) against all investigated clinically relevant fungal pathogens, except for C. glabrata, that the MIC values are close to the ones obtained for fluconazole, the standard antifungal agent tested. Preliminary structure-activity relations (SAR) might be suggested and a strong influence from steric and lipophilic parameters in the antifungal activity can be noticed. Cytotoxicity assays (IC50) showed that the complexes are not as toxic (IC50 values are much higher-30 to 200 fold-than MIC values). These ruthenium complexes are very promising lead compounds for novel antifungal drug development, especially in IFIs, one of most harmful emerging infection diseases (EIDs). |
| Doi | 10.3390/molecules19045402 |
| Pmid | 24879585 |
| Wosid | WOS:000336087800097 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |