Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery
Wu, Y; Jia, X; Lin, Y; Liu, D
| HERO ID | 2906601 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery |
| Authors | Wu, Y; Jia, X; Lin, Y; Liu, D |
| Journal | Key Engineering Materials |
| Volume | 602-603 |
| Page Numbers | 67-70 |
| Abstract | Mesoporous silica nanoparticles (MSNs) is an attractive candidate as a drug delivery carrier due to their large surface area, high pore volume and t intrinsic biocompatibility. Here, MSNs were synthesized by the hydrolysis and condensation of tetraethyl orthosilicate (TEOS) with cetyltrimethylammonium bromide (CTAB) acting as structural directing agent. A large mesopore with diameter of 3.8 to 5.5 nm of MCM-41style can be obtained via the addition of 1,3,5-trimethylbenzene. Metoprolol tartrate as a selective beta 1 receptor blocker was embedded on MSNs by the incipient wetness impregnation. The delivery profiles were collected in vitro in SBF at pH 7.4. A close correlation can be observed between the drug release kinetic and the mesopore size and specific surface area of MSNs. |
| Doi | 10.4028/www.scientific.net/KEM.602-603.67 |
| Wosid | WOS:000347939800016 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | MCM-41; tunable pore size; drug delivery |