Chronic skin absorption of propylene glycol methyl ether (33b) and dipropylene glycol methyl ether (50b) in rabbits
HERO ID
3041622
Reference Type
Technical Report
Year
2000
Language
English
| HERO ID | 3041622 |
|---|---|
| Year | 2000 |
| Title | Chronic skin absorption of propylene glycol methyl ether (33b) and dipropylene glycol methyl ether (50b) in rabbits |
| Authoring Organization | Dow Chemical Company |
| Abstract | Propylene glycol methyl ether (PGME) and dipropylene glycol methyl ether (DGME) were applied via occluded cotton pads to clipped, abraded abdominal skin of male rabbits (5/group; strain not reported) 5 times/week for 3 months. Control animals received distilled water via occluded cotton pads. Doses of 7 and 10 cc/kg PGME or 10 cc/kg DGME produced narcosis leading to death. No effects were seen at any dose on hematological parameters nor on gross appearance of organs. An increase in renal weight occurred with 10 cc/kg PGME. No observable effects were seen at doses of 1 or 5 cc/kg of either substance. |
| Ntis Number | OTS0520730 |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 20 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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