Levels of selected urinary metabolites of volatile organic compounds among children aged 6-11 years
Jain, RB
HERO ID
3042164
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 3042164 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Levels of selected urinary metabolites of volatile organic compounds among children aged 6-11 years |
| Authors | Jain, RB |
| Journal | Environmental Research |
| Volume | 142 |
| Page Numbers | 461-470 |
| Abstract | Data from National Health and Nutrition Examination Survey for the years 2011-2012 were used to evaluate variability in the observed levels of 20 urinary metabolites of volatile organic compounds (VOCs) by age, gender, and race/ethnicity among children aged 6-11 years. Exposure to environmental tobacco smoke was positively associated with the levels of selected metabolites of acrylonitrile, 1,3-butadiene, cyanide, and propylene oxide in a dose-response manner. Levels of the selected metabolites of acrolein, acrylonitrile, 1,3-butadiene, styrene, toluene, and xylene decreased with increase in age. Levels of 1-bromopropane decreased with number of rooms in the house but the reverse was true for 1,3-butadiene, carbon-disulfide, and N,N-dimethylformamide. Levels of most of the 20 metabolites did not vary with gender. Non-Hispanic white children had higher adjusted levels of N-Acetyl-S-(3,4-dihydroxybutyl)-l-cysteine (DHBMA), N-Acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC), and phenylglyoxylic acid (PGA) than non-Hispanic black children. Non-Hispanic white children had statistically significantly higher adjusted levels of N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-l-cysteine (GAMA), trans, trans-Muconic acid (MU), and N-Acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC) than non-Hispanic Asian children but statistically significantly lower levels of N-Acetyl-S-(n-propyl)-l-cysteine (BPMA) than non-Hispanic Asian children. Non-Hispanic Asian children had the lowest levels of 13 of the 20 metabolites among four major racial/ethnic groups but highest levels for three metabolites. For selected metabolites of acrolein, acrylamide, acrylonitrile-vinyl chloride-ethylene oxide, benzene, 1,3-butadien, crotonaldehyde, cyanide, ethylbenzene-styrene, and toluene, children had statistically significantly higher levels than nonsmoking adults. These results demonstrate how vulnerable children are to being exposed to harmful chemicals like VOCs in their own homes. |
| Doi | 10.1016/j.envres.2015.07.023 |
| Pmid | 26257031 |
| Wosid | WOS:000363602800053 |
| Url | https://search.proquest.com/docview/1727680948?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Urinary metabolites of volatile organic compounds; NHANES; Lifestyles; Environmental tobacco smoke |