Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene
Wepierre, J; Cohen, Y; Valette, G
HERO ID
3044744
Reference Type
Journal Article
Year
1968
Language
English
PMID
| HERO ID | 3044744 |
|---|---|
| In Press | No |
| Year | 1968 |
| Title | Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene |
| Authors | Wepierre, J; Cohen, Y; Valette, G |
| Journal | European Journal of Pharmacology |
| Volume | 3 |
| Issue | 1 |
| Page Numbers | 47-51 |
| Abstract | Percutaneous absorption of ethyl-alcohol (64175), perhydrosqualene (111013), and p-cymene (99876) was investigated. Male albino-mice were treated topically with 0.1 milliliter of radio labeled solutions of one of the test agents. In some tests with ethyl-alcohol and perhydrosqualene, the stratum corneum was removed before treatment. At selected times, the skin was removed and analyzed for radioactivity. Absorption rates were 10.5 and 0.12 nanomoles per square centimeter per minute for ethyl-alcohol and perhydrosqualene, respectively, for nonabraded skin. When the stratum corneum was removed, ethyl-alcohol penetration rate increased to 200 nanomoles per square centimeter per minute, but the rate for perhydrosqualene did not change. The penetration rate of p-cymene was 32 nanomoles per square centimeter per minute over 1 hour. The authors conclude that dermal absorption is affected by the epidermal barrier and the removal capacity of the blood. The liposolubility of the agent also affects its penetration through the epidermal stratum. |
| Doi | 10.1016/0014-2999(68)90047-2 |
| Pmid | 5654669 |
| Is Certified Translation | No |
| Dupe Override | 3044744 |
| Comments | Journal: European Journal of Pharmacology ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Percutaneous absorption; 14C ethyl alcohol 3H perhydrosqualene; 14C p-cymene |