The impact of litter effects on dose-response modeling in teratology
Kupper, LL; Poetier, C; Hogan, MD; Yamamoto, E
HERO ID
3252
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 3252 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | The impact of litter effects on dose-response modeling in teratology |
| Authors | Kupper, LL; Poetier, C; Hogan, MD; Yamamoto, E |
| Journal | Biometrics |
| Volume | 42 |
| Issue | 1 |
| Page Numbers | 85-98 |
| Abstract | The fitting of dose-response models to teratology data involving littermates in order to generate estimates of teratogenic risk is receiving increasing attention as a potential alternative to the "safety-factor" approach to risk estimation. In this paper, we utilize the beta-binomial distribution to introduce varying degrees of intralitter correlation, and, for purposes of illustration, consider a logistic dose-response model that describes the logit of risk as a straight-line function of ln(dose). The biases and (exact and asymptotic) variances of the maximum likelihood estimators of the intercept and slope are studied by simulation as a function of the intralitter correlation structure. |
| Doi | 10.2307/2531245 |
| Pmid | 3719065 |
| Wosid | WOS:A1986C904700007 |
| Url | http://www.jstor.org/stable/2531245 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Biometrics 42: 85-98. |
| Is Public | Yes |
| Language Text | English |