The metabolism of naphthalene in rabbits
Bourne, MC; Young, L
HERO ID
32764
Reference Type
Journal Article
Year
1934
Language
English
PMID
| HERO ID | 32764 |
|---|---|
| In Press | No |
| Year | 1934 |
| Title | The metabolism of naphthalene in rabbits |
| Authors | Bourne, MC; Young, L |
| Journal | Biochemistry |
| Volume | 28 |
| Issue | 3 |
| Page Numbers | 803-808 |
| Abstract | The metabolism of naphthalene (91203) was studied in rabbits. Naphthalene was dissolved in warm liquid paraffin and administered by a stomach tube to male rabbits. Doses of 1 or 2 grams (g) were given to each rabbit and repeated at intervals of 2 or 3 days. The alkaline urine excreted during the 24 hours following a 2g dose was collected and analyzed. Following feeding, naphthalene was not present in the alkaline urine but was rapidly formed on acidification from some soluble precursor present in the urine. This unidentified compound was not present in the urine of normal rabbits, and it did not appear after feeding liquid paraffin alone. From the 24 hour urine of a single rabbit fed 1g of naphthalene, 52 milligrams (mg) of the pure compound were obtained. The combined 24 hour urine of three rabbits administered 1g naphthalene each yielded 260mg of the compound. Yields of between 300 and 400mg of the pure compound were obtained from the 48 hour urine of three rabbits each administered a 2g dose. The authors conclude that naphthalene is metabolized in rabbits partly by conjugation with cysteine (52904) and is excreted as mercapturic-acid (616911). It is partly metabolized by conversion into a soluble compound, not yet identified, which yields naphthalene on acidification. |
| Doi | 10.1042/bj0280803 |
| Pmid | 16745465 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Biochem. J. 28: 803-808. |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-122734</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Animal studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolic study</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biological effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Urinalysis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Dose response</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biological factors</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Physiological response</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism</kw> |
| Is Qa | No |