Meat consumption and the risk of incident distal colon and rectal adenoma
Ferrucci, LM; Sinha, R; Huang, WY; Berndt, SI; Katki, HA; Schoen, RE; Hayes, RB; Cross, AJ
HERO ID
3378303
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 3378303 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Meat consumption and the risk of incident distal colon and rectal adenoma |
| Authors | Ferrucci, LM; Sinha, R; Huang, WY; Berndt, SI; Katki, HA; Schoen, RE; Hayes, RB; Cross, AJ |
| Journal | British Journal of Cancer |
| Volume | 106 |
| Issue | 3 |
| Page Numbers | 608-616 |
| Abstract | <strong>BACKGROUND: </strong>Most studies of meat and colorectal adenoma have investigated prevalent events from a single screening, thus limiting our understanding of the role of meat and meat-related exposures in early colorectal carcinogenesis.<br /><br /><strong>METHODS: </strong>Among participants in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who underwent baseline and follow-up sigmoidoscopy (n=17,072), we identified 1008 individuals with incident distal colorectal adenoma. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between meat and meat-related components and incident distal colorectal adenoma using multivariate logistic regression.<br /><br /><strong>RESULTS: </strong>We observed suggestive positive associations for red meat, processed meat, haeme iron, and nitrate/nitrite with distal colorectal adenoma. Grilled meat (OR=1.56, 95% CI=1.04-2.36), well or very well-done meat (OR=1.59, 95% CI=1.05-2.43), 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) (OR=1.75, 95% CI=1.17-2.64), benzo[a]pyrene (OR=1.53, 95% CI=1.06-2.20), and total mutagenic activity (OR=1.57, 95% CI=1.03-2.40) were positively associated with rectal adenoma. Total iron (diet and supplements) (OR=0.69, 95% CI=0.56-0.86) and iron from supplements (OR=0.65, 95% CI=0.44-0.97) were inversely associated with any distal colorectal adenoma.<br /><br /><strong>CONCLUSION: </strong>Our findings indicate that several meat-related components may be most relevant to early neoplasia in the rectum. In contrast, total iron and iron from supplements were inversely associated with any distal colorectal adenoma. |
| Doi | 10.1038/bjc.2011.549 |
| Pmid | 22166801 |
| Wosid | WOS:000300302300025 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856455767&doi=10.1038%2fbjc.2011.549&partnerID=40&md5=da18f1216266ce6bf4399a5cec2d688a |
| Is Public | Yes |
| Language Text | English |
| Keyword | Colorectal adenoma; Diet; Haeme iron; Meat; Meat mutagens; Nitrate; Nitrite |