Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment
Lipscomb, JC; Haddad, S; Poet, T; Krishnan, K
HERO ID
3514761
Reference Type
Journal Article
Subtype
Review
Year
2012
Language
English
PMID
| HERO ID | 3514761 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2012 |
| Title | Physiologically-based pharmacokinetic (PBPK) models in toxicity testing and risk assessment |
| Authors | Lipscomb, JC; Haddad, S; Poet, T; Krishnan, K |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 745 |
| Page Numbers | 76-95 |
| Abstract | Physiologically-based pharmacokinetic (PBPK) modeling offers a scientifically-sound framework for integrating mechanistic data on absorption, distribution, metabolism and elimination to predict the time-course of parent chemical, metabolite(s) or biomarkers in the exposed organism. A major advantage of PBPK models is their ability to forecast the impact of specific mechanistic processes and determinants on the tissue dose. In this regard, they facilitate integration of data obtained with in vitro and in silico methods, for making predictions of the tissue dosimetry in the whole animal, thus reducing and/or refining the use of animals in pharmacokinetic and toxicity studies. This chapter presents the principles and practice of PBPK modeling, as well as the application of these models in toxicity testing and health risk assessments. |
| Doi | 10.1007/978-1-4614-3055-1_6 |
| Pmid | 22437814 |
| Wosid | WOS:000333851400007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Risk Assessment; Toxicity Testing; PBPK Model; Health Risk Assessment; Cancer Risk Assessment |