National Particle Component Toxicity (NPACT) initiative: Study 2. In vitro and in vivo toxicity of exposure to coarse, fine, and ultrafine PM from five airsheds
Gordon, T; Lippmann, M; Nádas, A; Hickey, C
HERO ID
3520337
Reference Type
Technical Report
Subtype
HEI
Year
2013
Language
English
| HERO ID | 3520337 |
|---|---|
| Material Type | HEI |
| Year | 2013 |
| Title | National Particle Component Toxicity (NPACT) initiative: Study 2. In vitro and in vivo toxicity of exposure to coarse, fine, and ultrafine PM from five airsheds |
| Authors | Gordon, T; Lippmann, M; Nádas, A; Hickey, C |
| Publisher Text | Health Effects Institute |
| City | Boston, MA |
| Page Numbers | 55-93 |
| Abstract | A number of recent multi-city studies have reported associations between exposure to various ambient PM mass concentrations and human health effects. Because the toxicity of PM* varies with particle size, season, and location, PM mass concentration might not be the best indicator of PM-induced health effects. The overall aim of the current study was to investigate the role of PM composition on in vitro and in vivo acute toxicity. In coordination with Chen Study 1, we selected five U.S. airsheds — Manhattan, in New York City, New York; Sterling Forest State Park in Tuxedo, New York; East Lansing (for Study 1) and Ann Arbor (for Study 2) in Michigan; Seattle in Washington; and Anaheim (for Study 2) and the University of California–Irvine (for Study 1 and the 100-day study in Study 2) in the Los Angeles (LA) area of California — on the basis of expected differences in the source categories and chemical composition of the PM in these airsheds (as well as the presence of local collaborators with appropriate toxicologic expertise). |
| Report Number | 177 |
| Url | https://www.healtheffects.org/system/files/RR177-Lippmann.pdf |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 332 |
| Is Public | Yes |
| Language Text | English |
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