[The research of proteome profiling change of 1-bromopropane poisoning cases]
Miao, RM; Ding, BM; Zhang, YY; Wu, WM; You, DH; Fang, ZH; Zhao, R
HERO ID
3539580
Reference Type
Journal Article
Year
2016
Language
Chinese
PMID
| HERO ID | 3539580 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | [The research of proteome profiling change of 1-bromopropane poisoning cases] |
| Authors | Miao, RM; Ding, BM; Zhang, YY; Wu, WM; You, DH; Fang, ZH; Zhao, R |
| Journal | Zhonghua Laodong Weisheng Zhiyebing Zazhi / Chinese Journal of Industrial Hygiene and Occupational Diseases |
| Volume | 34 |
| Issue | 11 |
| Page Numbers | 835-838 |
| Abstract | Objective: This study was mainly focused on styudy on he proteome profile change between exposure to 1-Bromopropane (1-BP) and 1-BP poisoning. Methods: The samples of serums from exposure to 1-BP and 1-BP poisoning were collected and analyzed through Label free proteome technology platform. The differently expressed proteins between the two groups were quantified and identified, followed by function analysis by bioinformatics. Results: 127 proteins over 2 fold-change were selected, in which 39 proteins were up-regulated and 88 proteins were down-regulated. These different-ly expressed proteins were mainly involved in the process of enzyme active regulation, inflammatory reaction, protein modification, stress response, coagulation, transport. Conclusion: The differently expressed proteins provided the potential protein biomarkers for the early diagnosis of 1-BP poisoning and was beneficial for clinical diagnosis of 1-BP and understanding of the mechanism of 1-BP poisoning. |
| Doi | 10.3760/cma.j.issn.1001-9391.2016.11.010 |
| Pmid | 28043272 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Chinese |