Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals
Kennedy, GL
HERO ID
3749071
Reference Type
Journal Article
Year
1987
Language
English
PMID
| HERO ID | 3749071 |
|---|---|
| In Press | No |
| Year | 1987 |
| Title | Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals |
| Authors | Kennedy, GL |
| Journal | Toxicology Letters |
| Volume | 39 |
| Issue | 2-3 |
| Page Numbers | 295-300 |
| Abstract | The weight of the mouse liver following feeding of ammonium perfluorooctanoate, ammonium perfluorononanoate, Telomer B ammonium sulfate, and WG-III was increased in a dose-dependent manner. Dietary levels of 3 ppm or greater ammonium perfluorooctanoate for either 14 or 21 days produced a significant elevation in liver weight both on an absolute and on an organ/body weight ratio basis. Similarly, ammonium perfluorononanoate produced significant increases at the lowest level tested, 3 ppm. Telomer B ammonium sulfate and WG-III also produced liver weight increases but at higher feeding levels. The striking increase in liver weight following relatively short-term exposures in mice makes this a useful screening test for comparing the liver-enlarging capacity of ammonium perfluorooctanoate and related fluorochemicals. |
| Doi | 10.1016/0378-4274(87)90245-1 |
| Pmid | 3686556 |
| Wosid | WOS:A1987L209400021 |
| Url | https://search.proquest.com/docview/77845914?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Caprylates; Fluorocarbons; perfluorooctanoic acid; 947VD76D3L; Index Medicus; Dose-Response Relationship, Drug; Animals; Body Weight -- drug effects; Organ Size -- drug effects; Liver -- drug effects; Fluorocarbons -- toxicity; Liver -- pathology; Caprylates -- toxicity |
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