Exposure assessment of PM2.5 and urinary 8-OHdG for diesel exhaust emission inspector
Lee, MW; Chen, ML; Lung, SC; Tsai, CJ; Yin, XJ; Mao, IF
| HERO ID | 383171 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Exposure assessment of PM2.5 and urinary 8-OHdG for diesel exhaust emission inspector |
| Authors | Lee, MW; Chen, ML; Lung, SC; Tsai, CJ; Yin, XJ; Mao, IF |
| Journal | Science of the Total Environment |
| Volume | 408 |
| Issue | 3 |
| Page Numbers | 505-510 |
| Abstract | Animal studies have shown exposure to diesel exhaust particles (DEPs) to induce production of reactive oxygen species (ROSs) and increase levels of 8-hydroxydeoxyquanosine (8-OHdG). Controversial results have been obtained regarding the effects of workplace exposure on urinary 8-OHdG level. This study assessed concentrations of environmental PM(2.5) in DEP (DEP(2.5)), personal DEP(2.5) and urinary 8-OHdG of diesel engine exhaust emission inspector (inspector) at a diesel vehicle emission inspection station (inspection station). The analysis specifically focuses on the factors that influence inspector urinary 8-OHdG. Repeated-measures study design was used to sample for five consecutive days. A total of 25 environmental PM(2.5) measurements were analyzed at 5 different locations by using a dichotomous sampler, and a total of 55 personal PM(2.5) measurements were analyzed from inspectors by using PM(2.5) personal sampler. During the sampling period, a total of 110 pre- and post-work urine samples from inspectors, and 32 samples from the control group were collected. Following age and sex matching between the inspectors and the control group, levels of urinary 8-OHdG were analyzed. Environmental and personal concentrations of DEP(2.5) were 107.25+/-39.76 (mean+/-SD) and 155.96+/-75.70 microg/m(3), respectively. Also, the concentration of urinary 8-OHdG differed significantly between inspector and control non-smokers, averaging 14.05+/-12.71 and 6.58+/-4.39 microg/g creatinine, respectively. Additionally, urinary 8-OHdG concentrations were associated with diesel exposure after controlling for smoking and cooking at home. Compared with the control group, the inspector displayed significantly increased levels of urinary 8-OHdG. Diesel exhaust is the single pollutant involved in the exposure of DEP(2.5) at the inspection station, as confirmed by the final results. |
| Doi | 10.1016/j.scitotenv.2009.10.012 |
| Pmid | 19896169 |
| Wosid | WOS:000273127000007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adult; Air Pollutants, Occupational/*analysis; Cookery; Female; Guanine/*analogs & derivatives/urine; Housing; Humans; Male; Occupational Exposure/*analysis; Particulate Matter/*urine; Retrospective Studies; Risk Assessment; Smoking; Vehicle Emissions/*analysis; *Workplace |
| Is Qa | No |