Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors
Kiss, LE; Ferreira, HS; Learmonth, DA
| HERO ID | 3860735 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors |
| Authors | Kiss, LE; Ferreira, HS; Learmonth, DA |
| Journal | Organic Letters |
| Volume | 10 |
| Issue | 9 |
| Page Numbers | 1835-1837 |
| Abstract | Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide. |
| Doi | 10.1021/ol800458k |
| Pmid | 18399636 |
| Wosid | WOS:000255311200042 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |