Testing of selected workplace chemicals for teratogenic potential with attachments, cover sheets and letter dated 02/25/81
HERO ID
4159368
Reference Type
Technical Report
Year
1981
Language
English
| HERO ID | 4159368 |
|---|---|
| Year | 1981 |
| Title | Testing of selected workplace chemicals for teratogenic potential with attachments, cover sheets and letter dated 02/25/81 |
| Authoring Organization | Litton Bionetics |
| Publisher Text | Shell Oil |
| City | Houston, TX |
| Page Numbers | 63 |
| Abstract | The reproductive toxicity and teratogenic potential of 19 industrial chemicals have been investigated during the past 3 years. Preliminary studies in rats, utilizing intraperitoneal treatments on days 1-15 of gestation, have been conducted on 10 chemicals: allyl chloride, bisphenol A, copper naphthenate, ethylene dibromide, hexachlorobutadiene, 2-mercaptobenzothiazole, methyl styrene, naphthalene, 2-nitropropane, and 1,2,3-trichloropropane. Studies in rats and rabbits, utilizing inhalation exposure on days 1-19 and 1-24, respectively, of gestation, have been conducted on 9 chemicals: butylene oxide, carbon disulfide, 2-ethoxyethanol, ethyl benzene, methyl bromide, nitrous oxide, styrene oxide, tetrachloroethylene, and trichloroethylene. In the preliminary studies, evidence of teratogenic potential was seen with allyl chloride and bisphenol A, and fetal toxicity was seen in the absence of maternal toxicity with methyl styrene and 2-nitropropane. In the inhalation studies, 2-ethoxyethanol was strongly embryotoxic at the higher exposure levels employed, and was teratogenic at the lower concentration. |
| Report Number | 8EHQ-0381-0386 |
| Ntis Number | OTS0204918 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ICF NOTE: Perc358 |
| Is Public | No |
| Language Text | English |
| Keyword | Toxicity; Industrial medicine; Chemical compounds; Exposure; Hazardous materials; Laboratory animals; Rabbits; Risk factors; Inhalation; Laboratory tests; Occupational safety and health; Concentration(Composition); Teratogenic potential; 2-Ethoxyethanol; Embryotoxicity |
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