Results of long-term carcinogenicity bioassay on vinyl acetate monomer in Sprague-Dawley rats
Minardi, F; Belpoggi, F; Soffritti, M; Ciliberti, A; Lauriola, M; Cattin, E; Maltoni, C
HERO ID
42320
Reference Type
Journal Article
Year
2002
Language
English
PMID
| HERO ID | 42320 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Results of long-term carcinogenicity bioassay on vinyl acetate monomer in Sprague-Dawley rats |
| Authors | Minardi, F; Belpoggi, F; Soffritti, M; Ciliberti, A; Lauriola, M; Cattin, E; Maltoni, C |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 982 |
| Page Numbers | 106-122 |
| Abstract | Vinyl acetate monomer (VAM) was administered in drinking water supplied ad libitum at doses of 5,000, 1,000, and 0 ppm (v/v) to 17-week-old Sprague-Dawley rats (breeders) and to 12-day embryos (offspring). Treatment lasted for 104 weeks; thereafter, animals were kept under control conditions until spontaneous death. VAM was found to cause an increase in total malignant tumors and in carcinomas and/or precursor lesions of the oral cavity, lips, tongue, esophagus, and forestomach. Based on these data, VAM must be considered a multipotent carcinogen. |
| Pmid | 12562631 |
| Wosid | WOS:000180752400006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. |
| Is Public | Yes |
| Language Text | English |
| Keyword | vinyl acetate monomer; carcinogenicity; long-term bioassay; rat |
| Is Qa | No |