Synthesis and characterization of biodegradable linear-hyperbranched barbell-like poly(ethylene glycol)-supported poly(lactic-ran-glycolic acid) copolymers through direct polycondensation
Lu, D; Duan, P; Liu, Tao; Li, J; Li, T; Lei, Z
| HERO ID | 4428556 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Synthesis and characterization of biodegradable linear-hyperbranched barbell-like poly(ethylene glycol)-supported poly(lactic-ran-glycolic acid) copolymers through direct polycondensation |
| Authors | Lu, D; Duan, P; Liu, Tao; Li, J; Li, T; Lei, Z |
| Journal | Polymer International |
| Volume | 63 |
| Issue | 2 |
| Page Numbers | 244-251 |
| Abstract | A series of biodegradable linear-hyperbranched barbell-like poly(ethylene glycol) (PEG)-supported poly(lactic-ran-glycolic acid) (PLGA) copolymers were synthesized with PEG, d,l-lactic acid aqueous solution, glycolic acid and gluconic acid (Glu) under bulk conditions. The branching density of the hyperbranched section was varied by controlling the molar ratio of Glu to hydroxyl-terminal groups of PEG ([Glu]/[OH]=1, 3.5, 6.0, 8.5). Chemical structures of these copolymers were confirmed using NMR spectroscopy. The molecular weights were determined using H-1 NMR group analysis and gel permeation chromatography, both results being consistent with one another. The results of hydrolytic degradation indicate that these copolymers can degrade completely in no more than three weeks. The thermal properties were evaluated using differential scanning calorimetry and thermogravimetric analysis. The results indicate that the glass transition temperatures and melt temperatures of these copolymers are not above 50 degrees C. The self-assembly behavior of the copolymers on hydrophilic surfaces was also investigated. The morphology of self-assembly films made of the copolymers was observed using atomic force microscopy, and the results indicate that these copolymers exhibit more inhomogeneous and rough structural orientated films on a silicon wafer substrate with increasing branching densities. Due to the favorable biodegradability and biocompatibility of the PLGA and PEG, the results suggest new possibilities for these novel structural amphiphilic linear-hyperbranched barbell-like copolymers as potential biomaterials. (c) 2013 Society of Chemical Industry |
| Doi | 10.1002/pi.4494 |
| Wosid | WOS:000329749200011 |
| Is Certified Translation | No |
| Dupe Override | 4428556 |
| Is Public | Yes |
| Keyword | biodegradable; amphiphilic; direct polycondensation; linear-hyperbranched |