The metabolism of 2,5-dimethylhexane in male Fischer 344 rats
Serve, MP
| HERO ID | 4674889 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | The metabolism of 2,5-dimethylhexane in male Fischer 344 rats |
| Authors | Serve, MP |
| Journal | Chemosphere |
| Volume | 22 |
| Issue | 1-2 |
| Page Numbers | 77-84 |
| Abstract | The urinary metabolites of 2,5-dimethylhexane (2,5-DMH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 2,5-dimethyl-1-hexanoic acid, 2,5-dimethyl-1,2-hexanediol, 2,5-dimethyl-1,5-hexanediol, 2,5-dimethyl-2,5-hexanediol and 2,5-dimethyl-5-hydroxy-1-hexanoic acid. Metabolism favored the formation of the diols. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Histopathologic examination revealed moderate hyaline droplet formation in the renal proximal tubule. |
| Doi | 10.1016/0045-6535(91)90266-G |
| Wosid | WOS:A1991FD99900008 |
| Url | http://linkinghub.elsevier.com/retrieve/pii/004565359190266G |
| Is Certified Translation | No |
| Dupe Override | 4674889 |
| Is Public | Yes |
| Language Text | English |
| Keyword | metabolism |
| Relationship(s) |
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