Application of Microemulsions in Dermal and Transdermal Drug Delivery
Santos, P; Watkinson, AC; Hadgraft, J; Lane, ME
| HERO ID | 4683804 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Application of Microemulsions in Dermal and Transdermal Drug Delivery |
| Authors | Santos, P; Watkinson, AC; Hadgraft, J; Lane, ME |
| Journal | Skin Pharmacology and Applied Skin Physiology |
| Volume | 21 |
| Issue | 5 (Sep 2008) |
| Page Numbers | 246-259 |
| Abstract | Microemulsions are thermodynamically stable colloidal dispersions of water and oil stabilized by a surfactant and, in many cases, also a cosurfactant. In the pharmaceutical field, microemulsions have been used as drug carriers for percutaneous, ocular, oral and parenteral administration. This review discusses some of the applications of microemulsions specifically for topical and transdermal applications. Microemulsion nomenclature and composition, with particular emphasis on choice of surfactant and cosurfactant, is discussed. Methods used to characterize microemulsions are reviewed. Microemulsion formulations for dermal and transdermal delivery of pharmaceutical agents with particular emphasis on anti-inflammatory and anaesthetic agents are critically evaluated. Finally, the issues which warrant further investigation by researchers in order to realize the full potential of the technology are discussed. Copyright © 2008 S. Karger AG, Basel [PUBLICATION ABSTRACT] Microemulsions are thermodynamically stable colloidal dispersions of water and oil stabilized by a surfactant and, in many cases, also a cosurfactant. In the pharmaceutical field, microemulsions have been used as drug carriers for percutaneous, ocular, oral and parenteral administration. This review discusses some of the applications of microemulsions specifically for topical and transdermal applications. Microemulsion nomenclature and composition, with particular emphasis on choice of surfactant and cosurfactant, is discussed. Methods used to characterize microemulsions are reviewed. Microemulsion formulations for dermal and transdermal delivery of pharmaceutical agents with particular emphasis on anti-inflammatory and anaesthetic agents are critically evaluated. Finally, the issues which warrant further investigation by researchers in order to realize the full potential of the technology are discussed. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |