Development of nanovesicular systems for dermal imiquimod delivery: physicochemical characterization and in vitro/in vivo evaluation
Ma, Man; Wang, J; Guo, F; Lei, M; Tan, F; Li, Nan
| HERO ID | 4683807 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Development of nanovesicular systems for dermal imiquimod delivery: physicochemical characterization and in vitro/in vivo evaluation |
| Authors | Ma, Man; Wang, J; Guo, F; Lei, M; Tan, F; Li, Nan |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 26 |
| Issue | 6 (Jun 2015) |
| Page Numbers | 1 |
| Abstract | The aim of the current investigation was to develop and statistically evaluate nanovesicular systems for dermal imiquimod delivery. To this purpose, transethosomes were prepared with phospholipid, ethanol and different permeation enhancers. Conventional ethosomes, with soy phospholipid and ethanol, were used as control. The prepared vesicles were characterized for size, zeta potential, stability and entrapment efficiency. The optimal transethosomal formulation with mean particle size of 82.3 ± 9.5 nm showed the higher entrapment efficiency (68.69 ± 1.7 %). In vitro studies, permeation results of accumulated drug and local accumulation efficiency were significantly higher for transethosomes (24.64 µg/cm^sup 2^ and 6.70, respectively) than control (14.45 µg/cm^sup 2^ and 3.93, respectively). Confocal laser scanning microscopy of rhodamine 6G-loaded transethosomes revealed an enhanced retention into the deeper skin layers as compared to conventional ethosomes. Besides, Fourier-transform infra-red spectroscopy studies were also performed to understand the mechanism of interaction between skin and carriers. What's more, results of in vivo studies indicated the transethosomes of imiquimod providing the most effectiveness for dermal delivery among all of the formulations. These results suggested that transethosomes would be a promising dermal carrier for imiquimod in actinic keratose treatment. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Biomedical materials; Drug delivery systems; Biomedical engineering; Nanomaterials |