Cobalt(III)-Binding of Gluconate and 2-Amino-2-Deoxy-Gluconate
Pfister, Max; Illi, S; Kluefers, P
| HERO ID | 4801136 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Cobalt(III)-Binding of Gluconate and 2-Amino-2-Deoxy-Gluconate |
| Authors | Pfister, Max; Illi, S; Kluefers, P |
| Journal | Zeitschrift für Naturforschung B |
| Volume | 68 |
| Issue | 5-6 |
| Page Numbers | 739-742 |
| Abstract | Two isomers of the [Co(tren)(D-Glc1A1,2H(-2)-(KO1,2)-O-2)](+) (1) chelate are formed in equal parts in the reaction of [Co(tren)Cl-2]Cl and sodium gluconate. In contrast, the gluconate's 2-amino-2-deoxy derivative glucosaminate formed a single isomer of [Co(tren)(D-Glc1A2N1H(-1)-(KN)-N-2, O-2)](2+) (2). Crystals of the OC-6-34 isomer of 1, [1a]PF6 center dot H2O, showed the support of the metal-binding site by intramolecular hydrogen bonds. Due to the inertness of the cobalt(III) chelates, spectroscopy on redissolved crystals of [la]PF6 center dot H2O allowed the separation of the two C-13 NMR signal sets of the isomeric mixture. In a DFT approach, a small energy difference explained the formation of two isomers in the case of the gluconate. A larger difference was obtained for the glucosaminate, in line with the known rules for the stereospecific amino acid-Co(tren) chelation. |
| Doi | 10.5560/ZNB.2013-3082 |
| Wosid | WOS:000323293300041 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Gluconate; 2-Amino-2-deoxy-gluconate; Glucosaminate; Cobalt(III) |