The interaction of education and cumulative lead exposure on the mini-mental state examination
Bleecker, ML; Lindgren, KN; Ford, DP; Tiburzi, MJ
HERO ID
48088
Reference Type
Journal Article
Year
2002
Language
English
PMID
| HERO ID | 48088 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | The interaction of education and cumulative lead exposure on the mini-mental state examination |
| Authors | Bleecker, ML; Lindgren, KN; Ford, DP; Tiburzi, MJ |
| Journal | Journal of Occupational and Environmental Medicine |
| Volume | 44 |
| Issue | 6 |
| Page Numbers | 574-578 |
| Abstract | SUMMARY The effect of lead exposure on neurobehavioral performance is modified by age. Whether educational achievement can serve as an effect modifier on the lead-cognitive performance relationship is examined. The Mini-Mental State Examination (MMSE) and the reading section of the Wide Range Achievement Test-Revised (WRAT-R), a measure of educational achievement, were administered to 256 lead smelter workers. The workers had a mean (standard deviation) age of 41 (7.9) years, education of 10 (2.8) years, employment duration of 17 (8.1) years, current blood lead of 28 (8.8) Ág/dL, and working lifetime integrated blood lead index (IBL) of 725 (434) Ág-yr/dL. The median (range) MMSE score was 29 (19 to 30). Multiple linear regression assessed the contribution of age, WRAT-R, education, alcohol intake, cigarette use, IBL, and IBL x WRAT-R on MMSE performance. A significant IBL x WRAT-R interaction examined by stratification found a significant dose-effect relationship between IBL and MMSE, but only in the 78 workers with a WRAT-R reading grade level below 6 years. Workers with higher educational achievement compensated for the effect of lead on cognitive performance. (J Occup Environ Med. 2002;44:574-578) |
| Doi | 10.1097/00043764-200206000-00021 |
| Pmid | 12085485 |
| Wosid | WOS:000176267200020 |
| Url | <Go to ISI>://BCI:BCI200200411953 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.J. Occup. Environ. Med. 44: 574-578. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |