Therapeutic efficacy of 188Re-liposome in a C26 murine colon carcinoma solid tumor model
Chang, YJ; Hsu, CW; Chang, CH; Lan, KL; Ting, G; Lee, TW
| HERO ID | 4850098 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Therapeutic efficacy of 188Re-liposome in a C26 murine colon carcinoma solid tumor model |
| Authors | Chang, YJ; Hsu, CW; Chang, CH; Lan, KL; Ting, G; Lee, TW |
| Journal | Investigational New Drugs |
| Volume | 31 |
| Issue | 4 |
| Page Numbers | 801-811 |
| Abstract | Nanoliposomes are good drug delivery systems that allow the encapsulation of drugs into vesicles for their delivery. The objective of this study is to investigate the therapeutic efficacy of a new radio-therapeutics of (188)Re-labeled pegylated liposome in a C26 murine colon carcinoma solid tumor model. The safety of (188)Re-liposome was evaluated before radiotherapy treatment. The anti-tumor effect of (188)Re-liposome was assessed by tumor growth inhibition, survival ratio and ultrasound imaging. Apoptotic marker in tumor was also evaluated by the TUNEL (terminal deoxynucleotidyl transferase biotin-dUTP nick-end labeling) method after injection of (188)Re-liposome. The group treated with (188)Re-liposome displayed slight loss in body weight and decrease in white blood cell (WBC) count 7 to 14 days post-injection. With respect to therapeutic efficacy, the tumor-bearing mice treated with (188)Re-liposome showed better mean tumor growth inhibition rate (MGI) and longer median survival time (MGI = 0.140; 80 day) than those treated with anti-cancer drug 5-FU (MGI = 0.195; 69 day) and untreated control mice (MGI = 0.413; 48 day). The ultrasound imaging showed a decrease in both tumor volume and number of blood vessels. There were significantly more apoptotic nuclei (TUNEL-positive) in (188)Re-liposome-treated mice at 8 h after treatment than in control mice. These results evidenced the potential benefits achieved by oncological application of the radio-therapeutics (188)Re-liposome for adjuvant cancer treatment. |
| Doi | 10.1007/s10637-012-9906-7 |
| Pmid | 23224353 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |