Preparation, quality control and physico-chemical properties of Tc-99m-BAT-AV-45
Zhang, J; Zhou, X; Qin, X
| HERO ID | 4850269 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Preparation, quality control and physico-chemical properties of Tc-99m-BAT-AV-45 |
| Authors | Zhang, J; Zhou, X; Qin, X |
| Journal | Journal of Radioanalytical and Nuclear Chemistry |
| Volume | 292 |
| Issue | 3 |
| Page Numbers | 1377-1383 |
| Abstract | One novel styrylpyridine derivatives(AV-45) coupled with Tc-99m complex was synthesized. Tc-99m-BAT-AV-45 was prepared by a ligand exchange reaction employing sodium glucoheptonate, and effects of the amount of ligand, stannous chloride, sodium glucoheptonate and pH value of reaction mixture on the radiolabeling yield were studied in details. Quality control was performed by thin layer chromatography and high performance liquid chromatography. Besides the stability, partition coefficient and electrophoresis of Tc-99m-BAT-AV-45 were also investigated. The results showed that the average radiolabeling yield was (95 +/- 1%) and Tc-99m-BAT-AV-45 with suitable lipophilicity was stable and uncharged at physiological pH. |
| Doi | 10.1007/s10967-012-1657-6 |
| Wosid | WOS:000305232400061 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Styrylpyridine derivatives; Bisaminobisthiol; Technium-99m; beta-Amyloid Plaques; Single photon emission computed tomography (SPECT) |