Lead, a major environmental pollutant, is immunomodulatory by its differential effects on CD4+ T cell subsets
McCabe, MJ, Jr; Lawrence, DA
HERO ID
49230
Reference Type
Journal Article
Year
1991
Language
English
PMID
| HERO ID | 49230 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Lead, a major environmental pollutant, is immunomodulatory by its differential effects on CD4+ T cell subsets |
| Authors | McCabe, MJ, Jr; Lawrence, DA |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 111 |
| Issue | 1 |
| Page Numbers | 13-23 |
| Abstract | Studies were undertaken to address the necessity of B-T cell contact for the enhancement of B cell differentiation caused by the heavy metal lead (Pb). Membrane segregated cultures were used so that the influences of direct B-T cell contact and T cell factors on B cell differentiation could be independently evaluated. B-T cell contact was not absolutely required for Pb's enhancement of B cell maturation to antibody forming cells (AFCs); however, enhancement of the AFC response by Pb was optimal when B-T cell interactions were allowed. These results were corroborated by use of anti-L3T4 (mouse CD4) to block CD4+ T cell-B cell interaction. Blockade of B-T cell contact with anti-L3T4 did not inhibit the enhancement of the AFC response by Pb. Additional experimentation showed that Pb enhanced the AFC response and Ig production in the presence of antigen-specific T cell help, suggesting that Pb enhances B cell differentiation by augmenting cognate help rather than by inducing a response to Pb-altered-self. In studies employing antigen-specific T cell clones, Pb was found to differentially modulate antigen presentation to TH1 versus TH2 T cell clones, in that TH1 activation was inhibited and TH2 activation was enhanced by Pb. |
| Doi | 10.1016/0041-008X(91)90129-3 |
| Pmid | 1719661 |
| Wosid | WOS:A1991GN68400002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |