The decarboxylative Blaise reaction
Lee, JH; Choi, BS; Chang, JH; Lee, HB; Yoon, JY; Lee, J; Shin, H
| HERO ID | 4923586 |
|---|---|
| In Press | No |
| Year | 2007 |
| Title | The decarboxylative Blaise reaction |
| Authors | Lee, JH; Choi, BS; Chang, JH; Lee, HB; Yoon, JY; Lee, J; Shin, H |
| Journal | Journal of Organic Chemistry |
| Volume | 72 |
| Issue | 26 |
| Page Numbers | 10261-10263 |
| Abstract | Reaction of aryl nitriles with potassium ethyl malonate in the presence of zinc chloride and a catalytic amount of Hünig's base provided beta-amino acrylates in moderate to good yield. Compared to the classical Blaise reaction, this reaction is safer (endothermic), devoid of lacrimatory reagent, and is possible with 0.5-1.0 equiv of zinc chloride. |
| Doi | 10.1021/jo701743m |
| Pmid | 18047371 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |