Direct synthesis of 1,1'-[1,4-phenylenebis(methylene)]-bis- 1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups
Achmatowicz, M; Hegedus, LS
| HERO ID | 4923635 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | Direct synthesis of 1,1'-[1,4-phenylenebis(methylene)]-bis- 1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups |
| Authors | Achmatowicz, M; Hegedus, LS |
| Journal | Journal of Organic Chemistry |
| Volume | 68 |
| Issue | 16 |
| Page Numbers | 6435-6436 |
| Abstract | A four-step synthesis of the title compound starting from methyl acrylate, ethylenediamine, and dimethyl malonate is reported. The synthesis can be run on a multigram scale and is operationally simple. The use of protecting groups is avoided by utilizing the trioxocyclam as the key coupling intermediate. |
| Doi | 10.1021/jo030146r |
| Pmid | 12895083 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |