High enantioselectivity in rhodium-catalyzed allylic alkylation of 1-substituted 2-propenyl acetates
Hayashi, T; Okada, A; Suzuka, T; Kawatsura, M
| HERO ID | 4923666 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | High enantioselectivity in rhodium-catalyzed allylic alkylation of 1-substituted 2-propenyl acetates |
| Authors | Hayashi, T; Okada, A; Suzuka, T; Kawatsura, M |
| Journal | Organic Letters |
| Volume | 5 |
| Issue | 10 |
| Page Numbers | 1713-1715 |
| Abstract | [reaction: see text] Rhodium-catalyzed asymmetric allylic alkylation of 1-substituted 2-propenyl acetates with dimethyl malonate proceeded with high enantioselectivity in the presence of cesium carbonate as a base and a rhodium catalyst generated from Rh(dpm)(C(2)H(4))(2) (dpm = dipivaloylmethanato) and a chiral phosphino-oxazoline whose basic skeleton is axially chiral binaphthyl to give branch alkylation products in greater than 90% ee. |
| Doi | 10.1021/ol0343562 |
| Pmid | 12735759 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |