Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands
Ravera, M; Gabano, E; Sardi, M; Ermondi, G; Caron, G; Mcglinchey, MJ; Müller-Bunz, H; Monti, E; Gariboldi, MB; Osella, D
| HERO ID | 4924301 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands |
| Authors | Ravera, M; Gabano, E; Sardi, M; Ermondi, G; Caron, G; Mcglinchey, MJ; Müller-Bunz, H; Monti, E; Gariboldi, MB; Osella, D |
| Journal | Journal of Inorganic Biochemistry |
| Volume | 105 |
| Issue | 3 |
| Page Numbers | 400-409 |
| Abstract | The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis(imidazole) derivatives - the so-called Joseph ligands - are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity. |
| Doi | 10.1016/j.jinorgbio.2010.12.002 |
| Pmid | 21421126 |
| Wosid | WOS:000289494100009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |