Synthesis of Phosphoester Compounds Using Lactic Acid for Encapsulation of Paclitaxel
Takeuchi, I; Mikuni, R; Makino, K
| HERO ID | 4929236 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Synthesis of Phosphoester Compounds Using Lactic Acid for Encapsulation of Paclitaxel |
| Authors | Takeuchi, I; Mikuni, R; Makino, K |
| Journal | Anticancer Research |
| Volume | 38 |
| Issue | 6 |
| Page Numbers | 3401-3406 |
| Abstract | <strong>BACKGROUND/AIM: </strong>In the use of paclitaxel, side-effects caused by itself or solubilizing agents have become a major obstacle. In this study we aimed to synthesize biocompatible and degradable compounds for micelles to be used as carriers for paclitaxel.<br /><br /><strong>MATERIALS AND METHODS: </strong>Methoxypolyethylene glycol-lactate was obtained from methyl lactate and methoxypolyethylene glycol having a molecular weight of 350. Monoalkoxy phosphoryl chlorides were obtained from phosphoryl chloride and four kinds of linear alcohols. Then, four kinds of alkyl di(methoxypolyethylene glycol-lactate) phosphates were obtained from them.<br /><br /><strong>RESULTS: </strong>The results of 1H NMR spectroscopy showed that alkyl di(methoxypolyethylene glycol-lactate) phosphates were successfully synthesized. When 1-dodecanol, 1-hexadecanol, 1-octadecanol, and 1-eicosanol were used as side chains, the yields were 73.5±4.2, 69.1±3.6, 72.2±2.8, and 71.8±3.7%, respectively. The spectrum of 31P NMR suggested the existence of optical isomers.<br /><br /><strong>CONCLUSION: </strong>Four kinds of phosphoester compounds for micelle preparations were synthesized using lactic acid. |
| Doi | 10.21873/anticanres.12607 |
| Pmid | 29848689 |
| Wosid | WOS:000449934200022 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |