Practical large scale synthesis of half-esters of malonic acid
Niwayama, S; Cho, H
| HERO ID | 4932621 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Practical large scale synthesis of half-esters of malonic acid |
| Authors | Niwayama, S; Cho, H |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 57 |
| Issue | 5 |
| Page Numbers | 508-510 |
| Abstract | A practical large-scale synthesis of monomethyl malonate and monoethyl malonate, which are among the most commonly applied half-esters in organic synthesis, is described, applying the highly efficient selective monohydrolysis of symmetric diesters we reported before. The optimal conditions with regard to the type of base, equivalent, co-solvents, and the reaction time have been examined for large-scale reactions. Monomethyl malonate and monoethyl malonate were obtained in high yields with near 100% purity within only half a day. The conditions of this selective monohydrolysis reaction are environmentally benign and straightforward, as it requires only water, a small proportion of a volatile co-solvent, and inexpensive reagents, and produces no hazardous by-products, and therefore the synthetic utility of this reaction in process chemistry is expected. |
| Pmid | 19420784 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |