A Practical and Enantiospecific Synthesis of (-)-(R)- and (+)-(S)-Piperidin-3-ols
Sureshbabu, M; Raghunadh, A; Ramulu, K; Dahanukar, VH; Syamkumar, UK; Kumardubey, P
| HERO ID | 4933332 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | A Practical and Enantiospecific Synthesis of (-)-(R)- and (+)-(S)-Piperidin-3-ols |
| Authors | Sureshbabu, M; Raghunadh, A; Ramulu, K; Dahanukar, VH; Syamkumar, UK; Kumardubey, P |
| Journal | Helvetica Chimica Acta |
| Volume | 97 |
| Issue | 11 (Nov 2014) |
| Page Numbers | 1507 |
| Abstract | A highly enantiospecific, azide-free synthesis of (-)-(R)- and (+)-(S)-piperidin-3-ol in excellent yield was developed. The key step of the synthesis involves the enantiospecific ring openings of enantiomerically pure (R)- and (S)-2-(oxiran-2-ylmethyl)-1H-isoindole-1,3(2H)-diones with the diethyl malonate anion and subsequent decarboxylation. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |